In a disappointing game against the Seahawks, the Lions seasoned a setback when operating back David Montgomery suffered an injury. Throughout the fourth quarter, Montgomery was taken off the field on a cart and escorted to the locker space. It was evident that Montgomery had an ice pack on his leg, and head coach Dan Campbell later confirmed that it was a thigh injury. Campbell stated that it appeared to be a thigh bruise, but additional assessment would be carried out the following day.

Regardless of the unfortunate turn of events, Montgomery had a commendable overall performance in his 1st dwelling game as a Lion. He carried the ball 16 occasions, accumulating a total of 67 yards and scoring a touchdown. Nevertheless, the loss of Montgomery resulted in rookie Jahmyr Gibbs stepping up to fill the gap. Gibbs managed to contribute with seven carries for 17 yards and also produced an effect in the passing game, with seven catches for 39 yards. However, their efforts had been not adequate to safe a victory, as the Lions in the end fell to the Seahawks with a final score of 37-31.