GLP-1 Drugs and the Myth of the ‘Ozempic Personality’: Examining Mood Changes in Patients with Diabetes and Obesity

The term “Ozempic personality” has been circulating on social media and some media outlets, describing the changes in behavior reported by people taking GLP-1 drugs for diabetes and obesity. These individuals have reported mood swings, increased anxiety, feelings of depression, anhedonia, decreased libido and interest in sex.

Healthline suggests that these changes may be linked to a change in dopamine production, the “pleasure hormone” that our brain releases when we anticipate reward or pleasure. Professor Derek Daniels, who studies the effects of GLP-1 drugs, notes that these drugs make us feel full more quickly by making the dopamine system less sensitive. However, it is unclear whether the drugs directly affect dopamine receptors or if they make us feel full before decreasing dopamine levels.

One possible explanation for mood changes among individuals taking GLP-1 drugs is the difficulty of eating less, losing weight and giving up favorite foods. This process can lead to mood swings as people often use sweets to soothe and reward themselves. It may not be the direct effect of Ozempic or similar drugs causing these mood changes but rather the challenging process of overcoming addiction to unhealthy foods.

Despite these reported changes in behavior, experts emphasize that GLP-1 drugs have been proven effective and safe for managing diabetes and obesity. It is important to promptly seek professional help if mental health issues arise while taking these medications. The term “Ozempic personality” may not accurately describe the effects of these drugs as they provide valuable benefits for managing chronic conditions.