• Fri. Jun 2nd, 2023

Scientists changed scales on chicken feet to feathers by tweaking a single gene


May 26, 2023

By tweaking a distinct gene, scientists have found a way to permanently transform the scales on a chicken’s feet into feathers. The benefits give new insight into the bird’s evolutionary origins from dinosaurs.

“Like birds, it is clear nowadays that a lot of dinosaurs had been partially covered with feathers as nicely as scales,” mentioned Michel Milinkovitch, a professor in the Division of Genetics and Evolution at the University of Geneva and co-author of the new analysis. “In birds, it is comparable. So, by altering this gene, we can truly expand or reduce the proportion of the physique that is covered by feathers or scales based on when this gene is specifically expressed.”

To execute this genetic switcheroo, scientists in Switzerland targeted the sonic hedgehog gene (Shh), which controls a signaling pathway that determines the improvement of specific qualities though at the embryonic level. This involves the brain and spinal cord limbs and skin appendages, like scales and feathers, according to the study, published Might 17 in the journal Science Advances. (And, yes, Shh is named immediately after the titular character of the well-liked video game.)

In the lab, scientists made use of a procedure recognized as “egg candling,” which entails applying a light supply to illuminate the blood vessels inside an egg. This enabled them to determine a appropriate vessel to straight inject the building embryo with a molecule that activates the Shh pathway. For the study, they made use of broiler chickens (Gallus gallus domesticus), which are raised for industrial meat production, according to a statement.

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“We carried out the injection on day 11, which is the precise time when scales generally arise on the embryo,” lead author Rory Cooper, a postdoctoral fellow in artificial and all-natural evolution at the University of Geneva, told Reside Science. “If we execute the injection even a single day also late, the embryo has currently begun building scales.”

Just after the eggs hatched, the scientists noticed the formation of downy juvenile feathers on the chicks’ feet. These supersoft feathers had been comparable to the feathers covering the rest of their bodies, according to the statement.

“The impact is truly clear when they hatch,” Cooper mentioned. “And the alter lasts. After the chickens create the feathers, they do not go back to possessing scales on the targeted location.”

The researchers had been shocked at how straightforward it was to shape-shift the chickens’ feet and mentioned it gives the group a new understanding of how these animals evolved.

“Feathers are a function of alter,” Milinkovitch told Reside Science. “In dinosaurs, feathers could have been made use of to regulate the animal’s internal temperature or as a colorful show. Flight came later. By altering the expression of a single gene, we had been in a position to make a cascade of developmental effects that triggered feather development, supplying new insights into the evolution of these animals.”