According to Sadhu, insulin resistance can disrupt the ovarian cycle, leading to infertility by impacting hormones like estrogen and testosterone as well as the release of eggs from the ovaries. GLP-1 agonists have been found to reduce insulin resistance and improve fertility in patients. However, the effects of these drugs on pregnancy are still unknown, so patients should discuss any plans for becoming pregnant with their doctors and consider contraceptive strategies.
On the other hand, drugs like Ozempic and Mounjaro have been shown to have unexpected side effects such as reduced desire to smoke or drink. These findings suggest that there may be a connection between GLP-1 agonists and addiction. Luba Yammine, an addiction researcher, suggests that the part of the brain responsible for food cravings may also play a role in cravings for substances of abuse.
In recent years, GLP-1 drugs have shown promise as potential anti-addiction medications due to their ability to reduce insulin resistance. Christian Hendershot, an addiction researcher, notes that there are limited medications available for treating addiction and patients often struggle to access them. Furthermore, addiction research receives less funding compared to other diseases.