In a study involving over 350,000 individuals of European descent, researchers gathered data on their genetics, education, socioeconomic status, and disease history. Each subject was given a genetic risk score to summarize the influence of multiple genes on their lifespan as well as a score based on their adherence to healthy lifestyle principles. The subjects were then followed for an average of 13 years to assess their life expectancy.
The findings revealed that individuals with an unhealthy lifestyle faced a 78% higher risk of early death, regardless of their genetic risks. Those with a genetic predisposition to a shorter lifespan who also had an unhealthy lifestyle were twice as likely to die prematurely compared to those without genetic risks and a healthy lifestyle. The study also demonstrated that individuals with a genetic predisposition to diseases could reduce their risk of premature mortality by 62% through adopting a healthy lifestyle, potentially extending their life expectancy by up to 5 and a half years.
The researchers identified four key factors that significantly reduced the risk of premature mortality: regular physical activity, sufficient sleep duration, a healthy diet, and avoidance of smoking. Prof. Eitan Friedman emphasized the impact of lifestyle on gene expression, highlighting that while genes are fixed, lifestyle choices can influence gene expression and potentially affect health outcomes.
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Overall, the study highlights the importance of adopting a healthy lifestyle in reducing the risk of premature mortality for individuals with or without genetic risks. It also emphasizes that while genes may play a role in determining our health outcomes, it is ultimately our lifestyle choices that have the greatest impact on our overall health.